When you're tearing along at 75mph, bouncing all over the place, on your side, nose up, nose down, etc, the fuel in the tank is sploshing about all over the place like a fkkn washing machine!, it's very easy to draw some aireated fuel from this scenario, especially if you're low-ish on fuel.
A fuel tank with a sump helps.
In our race boat, we had a separate reservior/fuel-air separator, with internal baffles, and a high volume pump filling this from the main fuel tank, and a return from the top of the reservior, back to the tank.
This reserviour was tall (18") and quite narrow (body was 4" dia tube) the main high pressure fuel injection pump, then drew it's supply from the bottom of the reservior, ensuring a stable airless supply at all time. The return from the fuel pressure regulator at the fuel rail, returned to the reservior/air separator.
Before this system was installed, toward the end of a race, the motor would start to run real shitty as the Mercruiser system for coping with aireated fuel became inadequate.
To make re-engining easy, (as some boats don't have easy acces to the fuel tanks, so fitting a return line could be hard), Mercruiser fitted a system with a float & valve in a chamber to remove any air that came from the tank, this meant a return fuel line wasn't nessasary, this system was probably fine in a cruiser, or pleasure sports boat, but when your running flat out for an hour and a half, and need to be able to use all the fuel in the tanks, it was useless.
Another big issue with high power fuel injection, is making sure the bore of the fuel supply line is big enough, very often, the fitting used for things like filter heads, bulhead fittings and tank dip tubes etc, have a considerably smaller bore than the hose that they supposed to be used with, this results you thinking your 3/8" bore pipe is sufficient, and can't be the reason you have fuel starvation, but one of the fittings could have as little as 3/16" bore inside!, I've seen this many times, and I always rig such a system with 1/2" bore tube through-out, and check all fittings for 'free flow', and re-drill larger if needs be.
Run a fuel pressure gauge directly from the fuel rail to ensure you have adequate pressure "at the injectors".
All Just IMHO